Application Note: in vivo Bioluminescence Imaging of Myeloperoxidase Activity

Psoriasis is a chronic inflammatory disease affecting 1–3 % of the general population. Traditional systemic therapies for psoriasis, such as methotrexate, have a potential for long-term toxicity and may not always provide sufficient improvement of the condition.

This application note describes an experimental protocol enabling non-invasive, specific and rapid imaging of neutrophil infiltration occurring in an Imiquimod (IMQ)-induced mouse model of psoriasis-like dermatitis. Furthermore, with additional studies, it might be shown that BLI can be used along with or instead of the clinical method of ear thickness measurement, providing reliable data in a time-efficient and effective manner.


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